MOTS-C
Mitochondrial Peptide for Metabolic Health
MOTS-C is a mitochondrial-derived peptide encoded in the mitochondrial genome. Discovered by Dr. Changhan David Lee at USC, it acts as an exercise mimetic — activating AMPK and improving metabolic function in ways that parallel the benefits of physical exercise.
Starting at
$199/mo
16
Amino Acids
Mito
Derived
SC
Administration
$199
Per Vial
How MOTS-C Works
A mitochondrial signaling peptide that activates metabolic pathways similar to exercise
AMPK Activation
Activates AMP-activated protein kinase (AMPK), the master metabolic switch that regulates glucose uptake, fatty acid oxidation, and mitochondrial biogenesis.
Exercise Mimetic
Triggers metabolic adaptations similar to exercise — improved insulin sensitivity, enhanced fat oxidation, and increased cellular energy production.
Mitochondrial Signaling
As a mitochondrial-derived peptide, MOTS-C represents a novel class of signaling molecules that communicate mitochondrial status to the rest of the cell.
Why Choose MOTS-C?
Metabolic Enhancement
Improves glucose metabolism and insulin sensitivity through AMPK activation.
Fat Metabolism
Enhances fatty acid oxidation for improved body composition.
Exercise Mimetic
Activates metabolic pathways that parallel physical exercise benefits.
Mitochondrial Health
Supports mitochondrial biogenesis and function for cellular energy.
Longevity Potential
MOTS-C levels decline with age, and restoration may support healthy aging.
Insulin Sensitivity
May improve cellular glucose uptake and metabolic flexibility.
MOTS-C Protocol
Provider-customized metabolic optimization protocol
5-10mg 3x/week
Starting dose — subcutaneous injection
As directed
Adjusted based on metabolic response
Expected Results Timeline
All dosing determined by your prescribing provider.
Frequently Asked Questions
MOTS-C is a 16-amino acid peptide encoded in the mitochondrial genome. It was discovered at USC and represents a novel class of mitochondrial-derived signaling peptides that regulate metabolism.
MOTS-C activates AMPK, the same metabolic pathway activated by exercise. This leads to improved glucose uptake, enhanced fat oxidation, and increased mitochondrial function — benefits typically associated with physical activity.
No. MOTS-C activates some of the same pathways as exercise, but physical activity provides additional benefits (cardiovascular, musculoskeletal, neurological) that cannot be replicated by any peptide.
Individuals seeking metabolic optimization, those with insulin resistance, people looking to enhance exercise benefits, and those interested in longevity-focused protocols.
Optimize Your Metabolism
Start MOTS-C therapy for metabolic enhancement. Prepared by US-licensed 503A pharmacies.
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