PE-22-28
Enhanced Cognitive Function & Memory
PE-22-28 is a nootropic peptide derived from the protein Spadin that acts as a TREK-1 channel blocker. Research suggests it enhances cognitive function, memory formation, and may have antidepressant-like properties.
Starting at
$199/mo
Dual
Nootropic
BDNF
Enhancement
Nasal
Administration
$199
Per Vial
How PE-22-28 Works
A TREK-1 channel blocker that enhances neuronal excitability and cognitive function
Semax: BDNF Enhancement
Increases Brain-Derived Neurotrophic Factor (BDNF) expression, supporting neuroplasticity, memory formation, and cognitive function.
Selank: Anxiolytic Action
Modulates GABA and serotonin systems to reduce anxiety and stress without sedation or cognitive impairment — a 'clean' anxiolytic.
Synergistic Cognition
Together, Semax enhances cognitive performance while Selank removes the anxiety and stress that impair it — creating an optimal mental state.
Why Choose PE-22-28?
Enhanced Focus
Improved concentration and mental clarity through BDNF upregulation.
Anxiety Reduction
Selank's anxiolytic effects without sedation or cognitive impairment.
Memory Support
Enhanced memory formation and recall through neuroplasticity support.
Stress Resilience
Improved ability to perform under pressure and manage stress.
Neuroprotection
Both peptides demonstrate neuroprotective properties in research.
No Dependence
Non-addictive with no withdrawal effects or tolerance buildup.
Semax / Selank Protocol
Typically administered intranasally for rapid CNS absorption
200-400 mcg each, 1-2x daily
Starting dose — intranasal administration
As directed
Adjusted based on cognitive and mood response
Expected Results Timeline
All dosing determined by your prescribing provider.
Frequently Asked Questions
Semax is a synthetic analog of ACTH (4-10) that enhances BDNF. Selank is a synthetic analog of tuftsin with anxiolytic properties. Both were developed at the Institute of Molecular Genetics in Russia and have been used clinically for decades.
Many users report noticeable effects within the first few doses — improved focus from Semax and reduced anxiety from Selank. Full cognitive benefits develop over 2-4 weeks.
No. Neither Semax nor Selank produces dependence, tolerance, or withdrawal effects. They work through neurotrophic and modulatory mechanisms rather than direct receptor agonism.
Yes. The Semax/Selank combination is popular among professionals and students seeking enhanced cognitive performance without the side effects of stimulants.
Enhance Your Cognition
Start PE-22-28 therapy for cognitive enhancement. Prepared by US-licensed 503A pharmacies.
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